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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease amyloidosis
Comorbidity C0524851|neurodegenerative disease
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PubMedID- 24772437 In clinical practice, when a subject is evaluated because of cognitive symptoms, even if subtle, the demonstration of high brain amyloid load should strongly suggest one of the two main forms of neurodegenerative disease with amyloidosis, that is, ad or dlb.
PubMedID- 21916933 Significantly, calcium dysregulation is a pathological hallmark of other neurodegenerative diseases involving amyloidosis, for example alzheimer's disease, and this mechanism could explain the molecular events that drive amyloid toxicity in other neurodegenerative diseases.

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